1st Meeting : 02-09-08
(Guest Star : Miss Costrie)
-Talk about Genetic & Congential Malformation-
ψ Encephalocele => kepalanya b’isi berbagai cairan; otaknya jd tak bkembang.
ψ Anencephaly => tak punya batok kepala.
ψ Goldenhaar Syndrome => mulut lebar; telinga kiri mengalami rudimien (kemungkinan tuli); dll.
ψ Rubenstein Taybi Syndrome => mata katarak; over leg; ada timbunan lemak pd tgn & kaki; dll.
ψ Syndactily => tgn & kaki tidak normal; dll.
ψ Sebuah keanehan pd kelahiran adl tanda adanya keanehan** lain & mgkn lbh berbahaya.
ψ Congenital Malformation or Congenital Anomalies or Birth Defect are a developmental disorders present at birth.
ψ Congenital Anomalies are of 4 clinically :
1. Malformations : occur during formation of structure.
2. Disruptions : morphological alterations of structures after formation.
3. Deformation : due to mechanical forces that mold a part of fetus over a prolonged period of time.
4. Syndromes : group of anomalies occuring together with a specific common etiology.
ψ 3% bayi yg lahir pny kelainan (cacat).
ψ Rata** kelainan terlihat 6 % stlh 2 th; 8% stlh 5 th; 2 % stlh itu.
ψ Dr smw bayi yg cacat, 14% adl kelainan minor.
ψ USG dpt mendeteksi kelainan** pd janin.
ψ Ibu hamil diwajibkan periksa TORCH di bidan or Genekolog.
ψ Penyebab kelainan tsb adl genetik & lingk.
ψ Insiden** dr Malformation:
1. 2-3% dr kelahiran baru (4-6% stlh 5th)
2. 40-60% kelainan tak diketahui penyebabnya (genetik; lingk; ato genetik+lingk).
ψ Teratologi = ilmu ttg penyebab** abnormalitas.
ψ Prinsip Teratologi dikembangkan o/ Wilson pd 1959.
ψ Teratogen = subjek abnormal.
ψ Teratos dr bhs Yunani = monster.
ψ Teratogen** :
1. Obat**an (warfarin, valproic acid, phenytoin, dll).
2. Bhn** kimia (PCB, methyl-mercury, alcohol, dll).
3. Infeksi (rubella, herpes, sipilis, dll).
4. Radiasi ion (RTG,dll).
5. Faktor Ibu (Diabetes Melitus, PKU, hypertermia,dll).
ψ Penyebab** dr faktor lingk :
1. Infeksi.
2. Bhn** kimia.
3. Radiasi.
4. Hormon
5. Penyakit dr Ibu.
6. Kurang Gizi.
7. Hypoxia,dll.
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